When a man with an ACE score of six dies of a heart attack at fifty-five instead of seventy-five, the certificate reads myocardial infarction. When he overdoses at thirty, accidental poisoning. When he takes his own life at twenty-five, suicide. Three different codes. One root cause. Not one of those certificates says childhood.
Population Attributable Fraction analysis — the same method that established smoking as a cause of cancer. It asks how much of a given outcome would not occur if the exposure were removed. The full arithmetic, and the two reasons this figure is conservative, are published in the evidence brief.
This dose-response calculation remains the fundamental analytical threshold for evaluating chronic systemic risk.